The controls of Towns are currently unchangeable. While this may be changed in later releases, for now it is worth learning the basic controls.
Arrow Keys/WSAD - Navigate around the map.
R/E - Cycle through Townsfolk (useful for finding lost/fighting Townsfolk).
H - Cycle through Heroes
Q/C - Cycle through floors.
Shift - Hold down while placing items to place multiple copies. Similarly, holding while placing zones or orders (such as harvest/chop/etc) allows you to select multiple areas. When using the production menu, holding shift while selecting quantities will increase or decrease orders by 5.
Ctrl - Toggles transparency for walls and buildings.
T - Toggles the flattening of terrain, flora and buildings near the mouse cursor.
Z - Toggles global terrain, flora and building flattening.
Space - Pauses/unpauses the game.
F2 - Opens the Production Menu.
F3 - Opens the Priorities Panel.
F4 - Opens the Caravan menu.
F11 - Toggles Fullscreen mode.
G - Toggles Grid.
+/- - Toggles Game Speed.
ESC - Brings up the system menu (settings in tooltip) to save, save and quit, just quit, options and cancel to get back into the game